Synthesis and characterization of nanostructured noble metals for medical applications

用于医疗应用的纳米结构贵金属的合成和表征

• 批准号: 262754-2007
• 负责人: Burrell, Robert
• 金额: $ 1.8万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2007
• 资助国家: 加拿大
• 起止时间: 2007-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=364236
• 关键词: Synthesis; characterization; nanostructured; noble; metals

Silver nanostructured materials have recently been developed for use in wound treatment. These newmaterials, which are made of equiaxed crystals that are less than 20 billonths of a meter in diameter, have dramaticallychanged the lives of people with chronic wounds like pressure sores and venous ulcers. In the past some ofthese wounds would not heal despite receiving the best available treatment, but when treated withnanocrystalline silver they healed very well. Remarkably this same nanotechnology may one day benefitpeople with diverse diseases like eczema, psoriasis asthma and rheumatoid arthritis. This research programwill look at nanostructured noble metals, including gold, silver and platinum, with a goal of optimizing theirstructures to achieve various biological responses including control of inflammation. Researchers will usesophisticated vacuumn equipment to create various types of nanostructured materials and then use advancedchemical techniques to characterize the final materials. Biological activity assessments will also be made andcorrelated to the nanostructure of the material so that the structure-activity relationships can be established.This will allow researchers to optimize the materials nanostructure for various applications and make thedevelopment of therapeutic products possible.This work will keep Canada at the forefront of nanostructured materials research through the training ofgraduate students and postdoctoral fellows. It may lead to the development of new therapeutic agents whichwill benefit Canadians both by creating high tech employment opportunities in nanotechnology and byimproving their quality of life through the treatment of disease.

最近开发了银纳米结构材料用于伤口治疗。这些新材料由直径小于十亿分之一米的等轴晶体制成，极大地改变了患有压疮和静脉性溃疡等慢性伤口的人们的生活。过去，尽管接受了最好的治疗，其中一些伤口仍无法愈合，但当用纳米晶银治疗时，它们愈合得很好。值得注意的是，有一天，同样的纳米技术可能会让患有湿疹、牛皮癣、哮喘和类风湿关节炎等多种疾病的人受益。该研究计划将着眼于纳米结构的贵金属，包括金、银和铂，目标是优化它们的结构，以实现包括控制炎症在内的各种生物反应。研究人员将使用先进的真空设备来制造各种类型的纳米结构材料，然后使用先进的化学技术来表征最终材料。还将进行生物活性评估，并将其与材料的纳米结构相关联，以便建立结构-活性关系。这将使研究人员能够针对各种应用优化材料纳米结构，并使治疗产品的开发成为可能。这项工作将通过研究生和博士后的培训，使加拿大保持在纳米结构材料研究的前沿。它可能会导致新治疗剂的开发，通过创造纳米技术的高科技就业机会以及通过疾病治疗提高他们的生活质量，从而使加拿大人受益。