Low-pressure, fibre Bragg grating pressure sensors for measurement of cerebrospinal fluid pressures associated with spinal cord injury

低压光纤布拉格光栅压力传感器，用于测量与脊髓损伤相关的脑脊液压力

• 批准号: 360283-2008
• 负责人: Cripton, Peter
• 金额: $ 4.13万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Research Tools and Instruments - Category 1 (<$150,000)
• 财政年份: 2007
• 资助国家: 加拿大
• 起止时间: 2007-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=364329
• 关键词: Low; pressure; fibre; Bragg; grating

Spinal cord injury (SCI) is severe and debilitating with significant personal, social and economic costs. The complex mechanical interactions between the spinal cord and the surrounding cerebrospinal fluid (CSF) and dura both during and after SCI are not well understood. The equipment requested in this proposal will be used to construct a sensitive, low pressure range, Fibre Bragg Grating (FBG) pressure sensor array which is optimized for the high-rate measurement of in vivo CSF pressure prior to, during, and after an SCI in an animal model.In a collaboration between the University of Victoria and University of British Columbia, we have recently developed and implemented a sensor based on fibre-optic strain measurement, for the measurement of intervertebral disc pressures in the range of 0 to 3 MPa. The small size (400 µm diameter), mechanical compliance, immunity to electromagnetic interference, and biocompatibility, make this device ideal for biomedical applications. The current research will utilize a multi-sensor array with an improved light source and detection scheme which will extend its capabilities to the sub-kPa pressure range required for spinal fluid pressure measurement and improve the speed with which it can be measured.By studying the CSF pressure variation above and below the injury site in the hours following SCI, and during surgical decompression of the spinal cord we will provide important information to clinicians studying the feasibility of CSF drainage for spinal cord perfusion management. Also, By measuring the CSF pressure associated with spinal cord injury, we will provide important information to the basic science community, to inform and define the limitations of current animal, synthetic and computational models of SCI which do not currently consider the CSF interaction with the spinal cord and dura during acute SCI.

脊髓损伤（SCI）是严重的和衰弱的显着的个人，社会和经济成本。在SCI期间和之后，脊髓与周围的脑脊液（CSF）和硬脑膜之间复杂的机械相互作用还没有得到很好的理解。本提案中要求的设备将用于构建一个灵敏的、低压范围的光纤布拉格光栅（FBG）压力传感器阵列，该传感器阵列针对动物模型中SCI之前、期间和之后的体内CSF压力的高速测量进行了优化。在维多利亚大学和不列颠哥伦比亚省大学的合作中，我们最近开发并实现了一种基于光纤应变测量的传感器，用于测量0至3 MPa范围内的椎间盘压力。小尺寸（直径400 µm）、机械顺应性、抗电磁干扰性和生物相容性使该器件成为生物医学应用的理想选择。目前的研究将利用多传感器阵列，改进光源和检测方案，将其能力扩展到脊髓液压力测量所需的sub-kPa压力范围，并提高测量速度。通过研究SCI后数小时内损伤部位上方和下方的CSF压力变化，在脊髓减压手术中，我们将为临床医生研究脑脊液引流用于脊髓灌注管理的可行性提供重要信息。此外，通过测量与脊髓损伤相关的CSF压力，我们将为基础科学界提供重要信息，以告知和定义当前SCI的动物，合成和计算模型的局限性，这些模型目前没有考虑急性SCI期间CSF与脊髓和硬脑膜的相互作用。