Regulation of eicosanoid production in the fetal placenta in preterm labour

早产时胎儿胎盘中类二十烷酸产生的调节

• 批准号: nhmrc : 194423
• 负责人: Ian Young
• 金额: $ 17.14万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2002
• 资助国家: 澳大利亚
• 起止时间: 2002-01-01 至 2004-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-eicosanoid-production-preterm-labour/81728
• 关键词: Regulation; eicosanoid; production; fetal; placenta

Prostaglandins are fatty substances made within the body and they are what causes the pregnant uterus to contract and push out the fetus. At present we can't control preterm birth because we don't understand well enough how prostaglandin synthesis is controlled. New discoveries in our lab have suggested an exciting new possibility- that prostaglandins partially regulate their own synthesis. If we find this is so, there may be far-reaching implications for the ways in which anti-inflammatory drugs are used, not only in prevention of premature birth, but in inflammatory diseases too. Most research in this area has been directed toward understanding what controls the overall synthesis of prostaglandins, but there are several types of prostaglandins with different functions. we are now in a position to study, for the first time, how the synthesis of the specific prostaglandins is regulated in the pregnant uterus and how this changes during normal and preterm birth.

前列腺素是体内产生的脂肪物质，它们是导致怀孕子宫收缩并将胎儿推出的原因。目前我们还不能控制早产，因为我们还不太了解前列腺素的合成是如何控制的。我们实验室的新发现提出了一种令人兴奋的新可能性-如果我们发现这是真的，那么抗炎药的使用方式可能会产生深远的影响，不仅可以预防早产，还可以预防炎症性疾病。这一领域的大多数研究都是为了了解是什么控制了蓝草素的整体合成，但有几种类型的蓝草素具有不同的功能。我们现在能够第一次研究在怀孕子宫中如何调节特定的三尖杉脂素的合成，以及在正常和早产期间这种合成是如何变化的。