Instantaneous deposition rate of aerosols in the lung

气溶胶在肺部的瞬时沉积率

• 批准号: 250015-2007
• 负责人: Lange, Carlos
• 金额: $ 1.89万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2007
• 资助国家: 加拿大
• 起止时间: 2007-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=364662
• 关键词: Instantaneous; deposition; rate; aerosols; lung

The coordination of aerosol drug delivery with the breathing pattern of individual patients is one of the greatest challenges in developing the next generation of smart aerosol delivery devices. Accurate numerical simulation of aerosol deposition is essential for the optimal design and development of these new devices. The presently existing deposition models cannot capture the effect of transient breathing pattern and cannot predict the time dependent local deposition rates. The goal of this project is to develop novel deposition functions for the instantaneous, transient deposition rate of aerosol particles.The research will start with the development of new analytical deposition functions on highly simplified geometries to obtain functional forms that can be used in realistic flows. To adapt the analytical functions to realistic geometries, such as the mouth-throat and lung bifurcations, a novel experimental system will be developed. The working principle of this validation experiment is based on measuring electrical charge accumulation at surfaces to obtain the deposition rate of particles previously charged with a known unit charge. This setup will be the first of its kind to enable real-time measurement of local deposition rate of aerosol particles with high accuracy. An important feature of this experimental setup will be its ability to measure instantaneous local deposition rate at multiple locations simultaneously.The outcome of this research will greatly advance our ability to understand and to predict transient deposition rates of aerosols in different regions of lungs. This will help development of the next generation of smart nebulizers, which will offer a more efficient and better controlled, targeted delivery of drugs in human airways.

气雾剂药物输送与个体患者呼吸模式的协调是开发下一代智能气雾剂输送设备的最大挑战之一。气溶胶沉积的准确数值模拟对于这些新设备的优化设计和开发至关重要。目前现有的沉积模型无法捕捉瞬态呼吸模式的影响，也无法预测与时间相关的局部沉积速率。该项目的目标是为气溶胶颗粒的瞬时、瞬态沉积速率开发新颖的沉积函数。该研究将从在高度简化的几何形状上开发新的分析沉积函数开始，以获得可用于实际流动的函数形式。为了使分析函数适应现实的几何形状，例如口咽和肺分叉，将开发一种新颖的实验系统。该验证实验的工作原理是基于测量表面的电荷积累，以获得先前带有已知单位电荷的颗粒的沉积速率。该装置将是同类装置中第一个能够高精度实时测量气溶胶颗粒局部沉积率的装置。该实验装置的一个重要特点是能够同时测量多个位置的瞬时局部沉积率。这项研究的结果将极大地提高我们理解和预测肺部不同区域气溶胶瞬时沉积率的能力。这将有助于开发下一代智能雾化器，该雾化器将在人体呼吸道中提供更有效、更好控制的靶向药物输送。