Instantaneous deposition rate of aerosols in the lung

气溶胶在肺部的瞬时沉积率

• 批准号: 250015-2007
• 负责人: Lange, Carlos
• 金额: $ 1.89万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2009
• 资助国家: 加拿大
• 起止时间: 2009-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=426186
• 关键词: Instantaneous; deposition; rate; aerosols; lung

The coordination of aerosol drug delivery with the breathing pattern of individual patients is one of the greatest challenges in developing the next generation of smart aerosol delivery devices. Accurate numerical simulation of aerosol deposition is essential for the optimal design and development of these new devices. The presently existing deposition models cannot capture the effect of transient breathing pattern and cannot predict the time dependent local deposition rates. The goal of this project is to develop novel deposition functions for the instantaneous, transient deposition rate of aerosol particles.

气雾剂药物输送与个体患者呼吸模式的协调是开发下一代智能气雾剂输送设备的最大挑战之一。气溶胶沉积的准确数值模拟对于这些新设备的优化设计和开发至关重要。目前现有的沉积模型无法捕捉瞬态呼吸模式的影响，也无法预测与时间相关的局部沉积速率。该项目的目标是针对气溶胶颗粒的瞬时、瞬态沉积速率开发新颖的沉积函数。