Regulation and function of a novel fibroblast growth factor early response gene in embryonic development and cell differentiation

新型成纤维细胞生长因子早期反应基因在胚胎发育和细胞分化中的调控和功能

• 批准号: 194575-2007
• 负责人: Gillespie, Laura
• 金额: $ 2.04万
• 依托单位: Memorial University of Newfoundland
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Group
• 财政年份: 2007
• 资助国家: 加拿大
• 起止时间: 2007-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=364805
• 关键词: Regulation; function; novel; fibroblast; growth

The formation of all living organisms begins with the fertilization of a single cell, the egg. The discipline of developmental biology attempts to define the mechanisms that control how a single egg divides into billions of cells and how each of these cells specializes into the proper tissue type to give rise to a recognizable, fully functional organism. Cells in the embryo receive signals from their surroundings that tell them what to do, when to grow, when to specialize, what tissue to become. Cells pick up these signals, which are then transferred to the inside of the cell through a circuit that ends in the nucleus, the "brain" of the cell.  Upon receiving the signal, the nucleus issues a set of instructions that are translated into the appropriate action.The work in this proposal investigates a natural signal of the body, fibroblast growth factor (FGF), that plays a crucial role in embryonic development.  Recently, we have discovered a new gene, named mi-er1, which is activated when the FGF signal reaches the nucleus; mi-er1 controls activation of other genes and is important for proper development of the embryo.  Our research in this proposal is aimed at uncovering how this new FGF response gene works and how it is regulated. In this way, we will gain information about the molecules that help shape the embryo.

所有活着的有机体的形成始于单个细胞--卵子的受精。发育生物学的学科试图定义控制单个卵子如何分裂成数十亿个细胞的机制，以及每个细胞如何专门化成适当的组织类型，从而产生一个可识别的、功能齐全的有机体。胚胎中的细胞接收来自周围环境的信号，这些信号告诉它们要做什么，什么时候成长，什么时候专门化，变成什么组织。细胞获得这些信号，然后通过一个电路传递到细胞内部，最终到达细胞核，也就是细胞的“大脑”。一旦接收到信号，细胞核就发出一系列指令，这些指令被翻译成适当的行动。在这项提议中的工作是研究身体的一种自然信号，成纤维细胞生长因子(成纤维细胞生长因子)，它在胚胎发育中发挥关键作用。最近，我们发现了一种新的基因，名为mi-ER1，当成纤维细胞生长因子信号到达细胞核时，它被激活；MI-ER1控制其他基因的激活，对胚胎的正常发育非常重要。我们在这项提议中的研究旨在揭示这种新的成纤维细胞生长因子反应基因是如何发挥作用的，以及它是如何受到调控的。通过这种方式，我们将获得有关帮助塑造胚胎的分子的信息。