Regulation and function of a novel fibroblast growth factor early response gene in embryonic development and cell differentiation

新型成纤维细胞生长因子早期反应基因在胚胎发育和细胞分化中的调控和功能

• 批准号: 194575-2007
• 负责人: Gillespie, Laura
• 金额: $ 2.04万
• 依托单位: Memorial University of Newfoundland
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Group
• 财政年份: 2008
• 资助国家: 加拿大
• 起止时间: 2008-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=392538
• 关键词: Regulation; function; novel; fibroblast; growth

The formation of all living organisms begins with the fertilization of a single cell, the egg. The discipline of developmental biology attempts to define the mechanisms that control how a single egg divides into billions of cells and how each of these cells specializes into the proper tissue type to give rise to a recognizable, fully functional organism. Cells in the embryo receive signals from their surroundings that tell them what to do, when to grow, when to specialize, what tissue to become. Cells pick up these signals, which are then transferred to the inside of the cell through a circuit that ends in the nucleus, the "brain" of the cell. Upon receiving the signal, the nucleus issues a set of instructions that are translated into the appropriate action.

所有生物体的形成都始于一个单细胞即卵细胞的受精。发育生物学的学科试图定义控制单个卵子如何分裂成数十亿个细胞的机制，以及这些细胞中的每一个如何专门化为适当的组织类型，以产生可识别的，功能齐全的生物体。胚胎中的细胞从周围环境接收信号，告诉它们做什么，什么时候生长，什么时候分化，变成什么样的组织。细胞接收这些信号，然后通过一个终止于细胞核的电路将这些信号传递到细胞内部，细胞核是细胞的“大脑”。 在接收到信号后，细胞核发出一组指令，这些指令被翻译成适当的动作。