Regulation of growth hormone profile by metabolic balance: neuronal, neuroendocrinal and molecular mechanism

通过代谢平衡调节生长激素谱：神经元、神经内分泌和分子机制

• 批准号: nhmrc : 1029178
• 负责人: Prof Chen Chen
• 金额: $ 27.56万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-growth-hormone-molecular-mechanism/110674
• 关键词: Regulation; growth; hormone; profile; metabolic

Obesity is associated with a reduction in growth hormone secretion. As growth hormone maintains muscle mass at the expense of fat this may further promote the obese condition. This project will determine the physiological role of ghrelin, a hormone that signals hunger, in maintaining growth hormone secretion under normal, fasting and obese conditions. Clarification of the role of ghrelin in regulating growth hormone secretion may aid in the development of pharmacological agents to assist and maintain weight loss.

肥胖与生长激素分泌减少有关。由于生长激素以脂肪为代价维持肌肉质量，这可能进一步促进肥胖状况。该项目将确定生长激素释放肽（一种饥饿信号激素）在正常、禁食和肥胖条件下维持生长激素分泌的生理作用。阐明生长激素释放肽在调节生长激素分泌中的作用可能有助于开发药物来帮助和维持体重减轻。