New Methodologies for the Organic Modification of Solid Surfaces

将有机和生物有机分子固定在固体表面上是纳米技术和微阵列技术的中心目标。传感器和分子电子器件的发展与固定化技术和表面吸附物分子操纵和控制方法的进展直接相关。我的长期目标是开发分子电子器件，用于传感应用。我最初的重点是使这一技术成为现实所必需的化学的三个重要方面;（i）开发用有机分子对固体表面进行有效改性的新方法，（ii）对表面进行严格表征并研究薄膜的电化学性质，以及（iii）在高度局域水平上对吸附物的电化学操纵。导电（Au和Ag）以及半导电（Si）表面都将被研究。虽然SAM制备的大多数实验条件产生可再现的有机界面，具有某些应用可接受的特定理想功能，但其他基本性质仍需要进一步研究和优化，包括腐蚀和电化学性质。这与具有较低缺陷和增加的有序度的SAM的发展内在地相关。另一方面，无氧化物硅表面的有机改性提供了分子材料和固态半导体结构的直接结合，然后是技术上有用的和分子可调的薄膜的一种有吸引力的方法。这个建议的想法是利用我在基于电子转移反应的经验，电合成和SAM电化学，以开发表面衍生化和局部操作问题的化学解决方案。

The immobilization of organic and bioorganic molecules on solid surfaces is a central objective in nanotechnology and microarray technologies. Developments in sensors and molecular electronic devices are directly related to advances in immobilization techniques and methodologies for molecular manipulation and control of surface adsorbates. My long-term objective is the development of molecular electronic devices, for use in sensing applications. My initial thrust concerns three important aspects of the chemistry necessary to make this a realizable technology; (i) the development of new approaches for the efficient modification of solid surfaces with organic molecules, (ii) the rigorous characterization of surfaces and investigation of the electrochemical properties of the films, and (iii) the electrochemical manipulation of adsorbates on a highly local level.Both conducting (Au and Ag) as well as semiconducting (Si) surfaces will be investigated. While most experimental conditions for SAM preparation yield reproducible organic interfaces with specific desirable functionalities that are acceptable for some applications, other fundamental properties need still to be further studied and optimized including corrosion and electrochemical properties. This is intrinsically related to the development of SAMs with lower defects and increased order. On the other hand, the organic modification of oxide-free Si surfaces offering a direct combination of molecular materials and solid-state semiconductor structures and is then an attractive approach toward technologically useful and molecularly tunable thin films.The idea of this proposal is to use my experience in electron transfer based reactions, electrosynthesis and SAM electrochemistry to develop chemical solutions to the issues of surface derivatization and local manipulation.