Regulation of growth hormone action by sex steroids: metabolic implications for health and disease

性类固醇对生长激素作用的调节：对健康和疾病的代谢影响

• 批准号: nhmrc : 230854
• 负责人: Dr Kin-Chuen Leung
• 金额: $ 23.55万
• 依托单位: Garvan Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2003
• 资助国家: 澳大利亚
• 起止时间: 2003-01-01 至 2005-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-growth-hormone-health-disease/98218
• 关键词: Regulation; growth; hormone; action; sex

Fitness and health is determined by body composition, the amount of fat and lean tissue in the body. Obesity increases the risk of diabetes, blood pressure and heart attacks, while muscle wasting reduces strength and fitness. Body composition is controlled by hormones such as growth hormone (GH) which reduces body fat by stimulating its metabolism (burning) and increases lean tissue by stimulating protein synthesis. These metabolic actions of GH are exerted through the liver. This proposal seeks to understand how sex hormones control the amount of body fat and muscle in women and men. Based on previous research in our laboratory, we propose that sex hormones control the action of growth hormone on the liver. We will test the hypothesis that oestrogens impair the ability of the liver to burn fat and build protein in response to GH while male hormones have the opposite effect. The effect of oestrogen occurs only when oestrogen is taken as a tablet because the liver is exposed to high concentrations of this hormone after gut absorption. It causes postmenopausal women to gain fat and lose muscle. Apart from oestrogens, there are many other compounds with oestrogen-like activities such as phytooestrogens (oestrogens found in plants) and SERMs (used for treating osteoporosis). Their effect on the liver and body composition are unknown but important because of their widespread use in the community. The significance of these studies relate to optimising the benefits of oestrogen compounds by defining their metabolic effects on the liver. In men, understanding how male hormones work as anabolic agents may lead to ways of treating protein muscle wasting.

健身和健康是由身体成分，脂肪和瘦肉组织在体内的数量。肥胖会增加患糖尿病、高血压和心脏病的风险，而肌肉萎缩会降低力量和健康。身体成分由激素控制，如生长激素（GH），通过刺激新陈代谢（燃烧）减少身体脂肪，并通过刺激蛋白质合成增加瘦肉组织。GH的这些代谢作用是通过肝脏发挥的。这项提案旨在了解性激素如何控制女性和男性的身体脂肪和肌肉数量。根据我们实验室以前的研究，我们提出性激素控制生长激素对肝脏的作用。我们将测试的假设，雌激素损害肝脏的能力，燃烧脂肪和建立蛋白质的反应生长激素，而男性激素有相反的效果。雌激素的作用仅在雌激素作为片剂服用时发生，因为肝脏在肠道吸收后暴露于高浓度的这种激素。它会导致绝经后妇女增加脂肪和失去肌肉。除了雌激素，还有许多其他具有雌激素样活性的化合物，如植物雌激素（植物中发现的雌激素）和SERM（用于治疗骨质疏松症）。它们对肝脏和身体成分的影响尚不清楚，但由于其在社区中的广泛使用而非常重要。这些研究的意义在于通过确定雌激素化合物对肝脏的代谢作用来优化雌激素化合物的益处。在男性中，了解男性激素如何作为合成代谢剂工作可能会导致治疗蛋白质肌肉萎缩的方法。