Regulation of hypothalamic insulin & leptin signalling by TCPTP

下丘脑胰岛素的调节

• 批准号: nhmrc : 1002709
• 负责人: Prof Michael Cowley
• 金额: $ 50.58万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-hypothalamic-insulin-signalling-tcptp/108851
• 关键词: Regulation; hypothalamic; insulin; leptin; signalling

Insulin & leptin signal in the brain to lower blood glucose, suppress food intake, increase activity & increase energy expenditure. Obesity diminishes the abilities of insulin & leptin to signal. This proposal will determine if the enzyme TCPTP terminates insulin & leptin signaling in the brain. Our studies will provide insight into the molecular causes of obesity & may identify a novel therapeutic target for the treatment of obesity & type 2 diabetes.

胰岛素和瘦素在大脑中发出信号，降低血糖，抑制食物摄入，增加活动和增加能量消耗。肥胖降低了胰岛素和瘦素发出信号的能力。这一提议将确定TCPTP酶是否终止大脑中的胰岛素和瘦素信号。我们的研究将深入了解肥胖的分子原因，并可能为肥胖和2型糖尿病的治疗找到新的治疗靶点。