Development of an auto-positioning mandibular protruder for treatment of sleep apnea

开发用于治疗睡眠呼吸暂停的自动定位下颌前突

• 批准号: 356614-2007
• 负责人: Remmers, JohnEdward
• 金额: $ 4.24万
• 依托单位: University of Calgary
• 依托单位国家: 加拿大
• 项目类别: Idea to Innovation
• 财政年份: 2007
• 资助国家: 加拿大
• 起止时间: 2007-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=365389
• 关键词: Development; auto; positioning; mandibular; protruder

The project will develop an adaptive controlled mandibular protruder (ACMP). The ACMP is a medical device that will be used for the treatment of the 40+ million people who suffer from obstructive sleep apnea and high upper airway resistance. ACMP is an oral appliance designed and developed by Dr. John Remmers who is widely recognized as the founder of modern sleep apnea treatment (CPAP). Dr. Remmers ongoing work in this field has highlighted a need for new devices and management process that address low compliance issues associated with primary treatment options like CPAP. While oral appliances are not a new concept in the management of obstructive sleep apnea, current appliances, are known to cause dental and mandibular joint problems as a result of the forces needed to maintain the mandible in a fixed position throughout the night. The ACMP will respond to a number of measured physiologic parameters, continually optimizing the position of the mandible and minimizing the total forces applied to the mandible. The ACMP is expected to improve the therapeutic efficacy of dental devices, while minimizing side effects, such as tooth movement. The final development of the device will take advantage of technological advancements in miniaturization and physiologic monitoring, and produce an advanced prototype ready for regulatory testing at the end of the requested funding term.

该项目将开发一种自适应控制的下颌前突(ACMP)。ACMP是一种医疗设备，将用于治疗4000多万患有阻塞性睡眠呼吸暂停和上呼吸道阻力高的患者。ACMP是由约翰·雷默斯博士设计和开发的口腔矫治器，他被公认为现代睡眠呼吸暂停治疗(CPAP)的奠基人。Remmers博士在该领域正在进行的工作突显了对新设备和管理流程的需求，这些设备和管理流程可以解决与CPAP等初级治疗方案相关的低依从性问题。虽然口腔矫治器在治疗阻塞性睡眠呼吸暂停中并不是一个新概念，但目前的矫治器已被认为会导致牙齿和下颌关节问题，这是因为整夜保持下颌固定位置所需的力量的结果。ACMP将对一系列测量的生理参数做出反应，不断优化下颌的位置，并将施加在下颌上的总力降至最低。ACMP有望提高牙科设备的治疗效果，同时将副作用降至最低，如牙齿移动。该设备的最终开发将利用小型化和生理监测方面的技术进步，并生产出先进的原型，准备在所要求的资助期结束时进行监管测试。