Regulation of leukocyte lifespan by granzyme B and PI-9

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To fight infection or cancer the body produces specialized cells called cytotoxic lymphocytes (CLs) which target and eradicate abnormal cells. The number of CLs increases dramatically during infection, and decreases following infection. How this population decrease is controlled is not fully understood, but we propose that a protein used by the CL to kill targets also triggers suicide of the CL after it has destroyed a certain number of targets. How this is achieved is the focus of this project.