Regulation of leukocyte lifespan by granzyme B and PI-9

颗粒酶 B 和 PI-9 对白细胞寿命的调节

• 批准号: nhmrc : 491176
• 负责人: A/Pr Nigel Waterhouse
• 金额: $ 54.46万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-leukocyte-lifespan-pi-9/77493
• 关键词: Regulation; leukocyte; lifespan; granzyme; PI

To fight infection or cancer the body produces specialized cells called cytotoxic lymphocytes (CLs) which target and eradicate abnormal cells. The number of CLs increases dramatically during infection, and decreases following infection. How this population decrease is controlled is not fully understood, but we propose that a protein used by the CL to kill targets also triggers suicide of the CL after it has destroyed a certain number of targets. How this is achieved is the focus of this project.

为了对抗感染或癌症，身体会产生一种叫做细胞毒性淋巴细胞（CLs）的特殊细胞，这种细胞会瞄准并消灭异常细胞。CLs的数量在感染期间急剧增加，感染后减少。这种种群减少是如何被控制的尚不完全清楚，但我们提出，一种被CL用来杀死目标的蛋白质在摧毁了一定数量的目标后也会引发CL的自杀。如何实现这一点是本项目的重点。