Investigating mitochondrial outer membrane permeabilization during programmed cell death

研究程序性细胞死亡过程中线粒体外膜的透化作用

• 批准号: nhmrc : 566706
• 负责人: A/Pr Nigel Waterhouse
• 金额: $ 5.87万
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/investigating-mitochondrial-outer-cell-death/116014
• 关键词: Investigating; mitochondrial; outer; membrane; permeabilization

Cancer cells often contain defects which prevent their death. To kill cancer cells we must either reset or bypass these defects. Release of cytochrome c from mitochondria is a critical event in cell death and proteins that block this event render cells resistant to many cancer therapies. My research will determine how cytochrome c release occurs, how this event is regulated and how to kill cancer cells in which cytochrome c release is blocked.

癌细胞通常含有防止其死亡的缺陷。为了杀死癌细胞，我们必须重置或绕过这些缺陷。细胞色素c从线粒体中释放是细胞死亡的一个关键事件，阻止这一事件的蛋白质使细胞对许多癌症治疗产生抗性。我的研究将确定细胞色素c的释放是如何发生的，这一事件是如何调节的，以及如何杀死细胞色素c释放受阻的癌细胞。