Regulation of Mesenchymal to Epithelial Transitions by Netrin Receptors

Netrin 受体对间充质到上皮转变的调节

• 批准号: nhmrc : GNT1107123
• 负责人: Dr Michael Murray
• 金额: $ 64.7万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-mesenchymal-epithelial-netrin-receptors/1346560
• 关键词: Regulation; Mesenchymal; Epithelial; Transitions; Netrin

The formation of 2D cellular sheets is important during development, tissue repair, and tumor growth. The mechanisms involved, however, remain largely unknown. Recent findings in the fly and in human cells suggest Frazzled/Neogenin receptors drive this process, by establishing polarised scaffolds in the cell. We will test this hypothesis using fly genetics and analysis of 3-dimensional culture of mammalian cells. Our results will help guide future therapies for human disease.

二维细胞片层的形成在发育、组织修复和肿瘤生长过程中非常重要。然而，所涉及的机制在很大程度上仍然未知。最近在苍蝇和人类细胞中的发现表明，Frazzled/再生蛋白受体通过在细胞中建立极化支架来驱动这一过程。我们将使用果蝇遗传学和哺乳动物细胞的三维培养分析来验证这一假设。我们的研究结果将有助于指导未来的人类疾病治疗。