Regulation of the placental renin-angiotensin system by microRNAs; implications for pregnancies complicated by placental insufficiency?

microRNA对胎盘肾素-血管紧张素系统的调节；

• 批准号: nhmrc : 1043537
• 负责人: E/Pr Eugenie Lumbers
• 金额: $ 32.21万
• 依托单位: The University of Newcastle
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-placental-renin-placental-insufficiency/111586
• 关键词: Regulation; placental; renin; angiotensin; system

Intrauterine growth restriction (IUGR) and preeclampsia (PrE) are life threatening to mother and baby, making the baby susceptible to disease as an adult. One of the major causes of PreE and IUGR is placentation. Placentation is affected by the placental renin-angiotensin system (RAS), which is controlled by microRNAs. We will describe these microRNAs, what controls them; determine their expression and RAS expression in normal pregnancy, IUGR and PrE, thus providing novel biomarkers for their early detection.

胎儿宫内发育迟缓(IUGR)和子痫前期(PRE)对母婴都有生命威胁，使婴儿成年后易患疾病。胎盘形成是导致胎盘早剥和宫内发育迟缓的主要原因之一。胎盘形成受胎盘肾素-血管紧张素系统(RAS)的影响，RAS是由microRNA控制的。我们将描述这些microRNAs，是什么控制着它们；检测它们在正常妊娠、IUGR和Pre中的表达和RAS的表达，从而为它们的早期检测提供新的生物标志物。