Regulation of virulence gene expression in Clostridium perfringens

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This project involves the analysis of a bacterium that causes gas gangrene. We have shown that a previously unknown regulatory protein modulates the ability of this bacterium to cause disease. We aim to determine what turns on the protein's activity, how it controls the factors that contribute towards disease and what specific factors are involved in disease. The major outcome will be a better understanding of the mechanisms of virulence gene regulation, which will lead to improved methods of disease control.