Regulatory interactions between YAP and Beta-catenin in normal epidermal homeostasis and in skin cancer

澳大利亚是世界上皮肤癌发病率最高的国家。我们发现癌蛋白雅普通过激活Wnt通路激活皮肤中的干细胞增殖，并且我们有证据表明雅普在人类皮肤癌中被过度激活。我们将绘制出雅普和Wnt通路在正常表皮稳态和皮肤癌中相互作用的分子本质。这项研究将为人类皮肤癌和其他再生性皮肤病的治疗途径的发展提供新的见解。

Australia has the highest skin cancer incidence in the world. We found that oncoprotein YAP activates stem cell proliferation in the skin through activation of the Wnt pathway, and we have evidence that YAP is hyperactivated in human skin cancer. We will map out the molecular nature of the interaction between YAP and the Wnt pathway in normal epidermal homeostasis and in skin cancer. This study will provide novel insights for development of therapeutic avenues for human skin cancer and other regenerative dermatological disorders.