课题基金 / 基金详情

Uncovering New Regulatory Mechanisms of Adiponectin Expression: Cooperation Between the Adipocyte and Adipose Tissue Microenv

Uncovering New Regulatory Mechanisms of Adiponectin Expression: Cooperation Between the Adipocyte and Adipose Tissue Microenv
揭示脂联素表达的新调控机制:脂肪细胞与脂肪组织微环境之间的合作
批准号:
9467119
负责人:
Clair Crewe
金额:
$5.71万
依托单位国家:
美国
项目类别:
财政年份:
2017
资助国家:
美国
项目状态:
已结题
起止时间:
2017-09-05 至 2020-04-30

项目摘要

项目成果

Clair Crewe的其他基金

相似基金

相关文献

中文摘要
翻译
项目总结
英文摘要
Project Summary The rising prevalence of obesity in developed countries has shown no signs of abating, putting society under monumental strain. The burden is both monetary and health-related, as obesity is a strong risk factor for the development of type II diabetes and its associated complications: coronary heart disease and stroke. Great progress has been made in our understanding of the pathology of obesity-related diseases, yet it is becoming clear that new approaches are needed to find pharmacological targets to treat metabolic dysfunction in a more effective way and with less side effects. One such approach is to target the function of adipose tissue, the organ at the forefront of metabolic disturbances in obesity. Adipose tissue produces a number of secreted factors that have profound effects on systemic metabolism. Most notably, adiponectin (Apn), which has been shown to have positive effects on insulin sensitivity and inflammation in obese mice. In fact, serum adiponectin is reduced in the obese state, an effect that has been shown to contribute to obesity-associated disease. To date, it has been challenging to find a practical way to harness the benefits of adiponectin. We have recently uncovered a regulatory mechanism that functions to limit adiponectin expression in adipocytes. In this project, I propose that if we can further understand this mechanism, we can find new therapeutic avenues to restore diminished adiponectin levels in obesity and, along with that, enhance systemic insulin sensitivity and reduce inflammation. We have generated the first transgenic mouse model that allows us to inducibly overexpress adiponectin in any tissue. Induction of Apn mRNA in liver or kidney resulted in the expected increase in serum Apn. Interestingly, induction of Apn in adipose tissue resulted in a decrease in serum Apn. Herein, I will detail this preliminary data and the experimental design to characterize this mechanism that restrains Apn expression specifically in the adipocyte and determine the efficacy of restoring Apn after the onset of obesity for enhancing insulin sensitivity.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Extracellular Vesiclemediated Regulation of Metabolism
  • 批准号:
    10666550
  • 项目类别:
  • 资助金额:
    $23.49万
  • 财政年份:
    2021
  • 负责人:
    Clair Crewe
  • 依托单位:
Extracellular Vesiclemediated Regulation of Metabolism
  • 批准号:
    10447851
  • 项目类别:
  • 资助金额:
    $24.9万
  • 财政年份:
    2021
  • 负责人:
    Clair Crewe
  • 依托单位:
Extracellular Vesicle‐mediated Regulation of Metabolism
  • 批准号:
    9805395
  • 项目类别:
  • 资助金额:
    $9.15万
  • 财政年份:
    2019
  • 负责人:
    Clair Crewe
  • 依托单位:
国内基金
海外基金
支链氨基酸代谢紊乱调控“Adipocytes - Macrophages Crosstalk”诱发2型糖尿病脂肪组织功能和结构障碍的作用及机制