The relationship between cognition and interictal discharges: language organization and spike localisation in BECTS

认知与发作间期放电之间的关系：BECTS 中的语言组织和尖峰定位

• 批准号: nhmrc : 318900
• 负责人: Dr Anthony Harvey
• 金额: $ 14.44万
• 依托单位: Brain Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2005
• 资助国家: 澳大利亚
• 起止时间: 2005-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/relationship-cognition-interictal-localisation-bects/82699
• 关键词: relationship; between; cognition; interictal; discharges

Benign epilepsy with centro-temporal spikes (BECTS, rolandic epilepsy) is a common cause of seizures in primary school children. Despite this it is poorly understood. Although seizures are infrequent, brainwave recordings (electroencephalography, EEG) reveal striking abnormalities present much of the time. Large, sharply contoured brain waves (spikes) are seen frequently, increasing during sleep. The pattern of the spikes, and the characteristic nature of seizures have suggested the epilepsy arises near the face area of the motor cortex, but this remains unproven. Functional magnetic resonance imaging (fMRI) is a safe and non-invasive way of imaging cerebral function, to reveal the brain at work . The technology is contributing to major advances in understanding of basic human functions such as language. Recent developments at the Brain Research Institute in Melbourne mean it is now possible to record EEG during fMRI. This has permitted visualisation of spike activity in the brain. The BRI is the only centre in Australia, and one of only a handful in the world that is able to perform such studies. One purpose of this study is reveal the location of spikes in BECTS. Recent studies have revealed subtle language and learning difficulties in BECTS children. Our preliminary EEG-fMRI studies have suggested spikes arise from brain regions adjacent to important language areas. It is possible that the frequent spikes of BECTS are interfering with adjacent cognitive processes. In addition to spike mapping, we will perform functional imaging of language to look for interactions between spike and language areas, and compare with patterns of language activation seen in normal children. The demonstration of spike related affects on cognition may lead to a reassessment of current epilepsy management strategies, which focus predominately on seizure control. This study, with researchers in Cairns and Melbourne, shares the benefits of world class research with regional Australia.

良性癫痫伴中央颞棘波（BECTS，罗兰式癫痫）是小学儿童癫痫发作的常见原因。尽管如此，人们对此知之甚少。虽然癫痫发作是罕见的，脑电波记录（脑电图，脑电图）显示显着的异常目前的大部分时间。大的，轮廓鲜明的脑电波（尖峰）经常出现，在睡眠期间增加。棘波的模式和癫痫发作的特征性性质表明癫痫发生在运动皮层的面部区域附近，但这一点尚未得到证实。功能磁共振成像（fMRI）是一种安全、无创的脑功能成像方法，可以揭示大脑的工作状态。这项技术正在促进对语言等基本人类功能的理解。墨尔本大脑研究所的最新进展意味着现在可以在功能磁共振成像中记录脑电图。这使得大脑中尖峰活动的可视化成为可能。BRI是澳大利亚唯一的中心，也是世界上少数几个能够进行此类研究的中心之一。本研究的目的之一是揭示BECTS中尖峰的位置。最近的研究表明，BECTS儿童存在微妙的语言和学习困难。我们初步的脑电功能磁共振成像研究表明，尖峰信号来自与重要语言区域相邻的大脑区域。BECTS的频繁尖峰可能干扰了相邻的认知过程。除了尖峰映射，我们还将进行语言功能成像，以寻找尖峰和语言区域之间的相互作用，并与正常儿童的语言激活模式进行比较。棘波对认知的影响可能会导致对目前癫痫管理策略的重新评估，这些策略主要集中在癫痫发作控制上。这项研究，与研究人员在凯恩斯和墨尔本，分享世界一流的研究与澳大利亚地区的好处。