Relaxin receptor structural determination to aid therapeutic development

肽激素松弛素的受体RXFP 1正被许多制药公司用于治疗心血管疾病。然而，缺乏松弛素如何结合和激活RXFP 1的分子细节阻碍了新药的开发。我们将确定与RXFP 1结合的松弛素复合物的结构及其激活细胞的机制。所获得的知识将有助于设计靶向RXFP 1治疗心血管疾病的新药。

The receptor for the peptide hormone relaxin, RXFP1, is being targeted by numerous drug companies for the treatment of cardiovascular disease. However, the lack of molecular detail of how relaxin binds and activates RXFP1 is hindering new drug development. We will determine the structure of the complex of relaxin bound to RXFP1 and the mechanism by which this activates cells. The knowledge gained will aid in the design of new drugs targeting RXFP1 for the treatment of cardiovascular disease.