Remodelling in Cardiac Hypertrophy: Implications for Arrhythmogenesis

心脏肥大的重塑：对心律失常发生的影响

• 批准号: nhmrc : 519173
• 负责人: Dr Dennis Lau
• 金额: $ 3.22万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Postgraduate Scholarships
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/remodelling-cardiac-hypertrophy-implications-arrhythmogenesis/115696
• 关键词: Remodelling; Cardiac; Hypertrophy; Implications; Arrhythmogenesis

High blood pressure (HBP) affects 1 in 3 adults. Cardiac hypertrophy (thickened heart muscles) is a common condition seen in HBP. This research seeks to study the underlying changes in electrical, structural and molecular properties of the heart that may contribute to the increased sudden death and atrial fibrillation (irregular heart rhythm) associated with both HBP and cardiac hypertrophy. The new understanding may identify new treatment targets to reduce these life-threatening conditions.

三分之一的成年人患有高血压 (HBP)。心脏肥大（心肌增厚）是 HBP 的常见病症。这项研究旨在研究心脏电、结构和分子特性的潜在变化，这些变化可能导致与 HBP 和心脏肥大相关的猝死和心房颤动（心律不齐）增加。新的认识可能会确定新的治疗目标，以减少这些危及生命的疾病。