Renal medullary blood flow: regulation by paracrine, endocrine and neural factors

肾髓血流：旁分泌、内分泌和神经因素的调节

• 批准号: nhmrc : 143603
• 负责人: A/Pr Simon Malpas
• 金额: $ 27.38万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2001
• 资助国家: 澳大利亚
• 起止时间: 2001-01-01 至 2005-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/renal-medullary-blood-neural-factors/97981
• 关键词: Renal; medullary; blood; flow; regulation

High blood pressure is a condition afflicting more than 10% of our community, and is the leading risk factor for stroke and heart disease. The kidneys play a critical role in control of blood pressure under normal conditions, and probably also in the initiation and maintenance of high blood pressure. This influence is exerted both through the excretion of salt and water, and by the release of substances into the circulation that affect blood pressure (hormones). Recent experiments performed by us and others have indicated that the inner part of the kidney (the medulla) is critical in these functions, which appear to be regulated by the level of blood flow in the medulla of the kidney. Our recent experiments also show that hormones and nerves have diverse effects on blood flow in the different regions of the kidney, showing that these factors can differentially affect blood pressure depending on their effects on medullary blood flow. Importantly, these hormones and nerves do not act in isolation, but act in concert, and in association with so called 'second messenger' systems that act locally to directly affect the contraction of muscle in blood vessels, and so blood vessel size. The experiments described in this application are aimed at determining how circulating and locally acting hormones, and the nerves in the kidney, interact together to control blood flow in the different regions of the kidney. This will help us understand how blood flow to the medulla of the kidney is regulated normally, so that we can begin to understand how malfunction of these systems can contribute to the development of high blood pressure.

高血压困扰着我们社区 10% 以上的人口，并且是中风和心脏病的主要危险因素。肾脏在正常情况下控制血压方面发挥着至关重要的作用，也可能在高血压的发生和维持中发挥着关键作用。这种影响是通过盐和水的排泄以及影响血压的物质（激素）释放到循环中来发挥的。我们和其他人最近进行的实验表明，肾脏的内部部分（髓质）对于这些功能至关重要，这些功能似乎受到肾髓质中血流水平的调节。我们最近的实验还表明，激素和神经对肾脏不同区域的血流有不同的影响，表明这些因素对血压的影响取决于它们对髓质血流的影响。重要的是，这些激素和神经并不是孤立地发挥作用，而是协同作用，并与所谓的“第二信使”系统相关联，该系统在局部发挥作用，直接影响血管中肌肉的收缩，从而影响血管的大小。本申请中描述的实验旨在确定循环和局部作用的激素以及肾脏中的神经如何相互作用以控制肾脏不同区域的血流。这将帮助我们了解流向肾髓质的血流是如何正常调节的，这样我们就可以开始了解这些系统的故障如何导致高血压的发生。