The role of tissue hypoxia in the evolution of kidney disease

组织缺氧在肾脏疾病演变中的作用

• 批准号: nhmrc : 1024575
• 负责人: A/Pr Simon Malpas
• 金额: $ 33.97万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-tissue-hypoxia-kidney-disease/110363
• 关键词: role; tissue; hypoxia; evolution; kidney

We will determine how low oxygen levels in the kidney lead to kidney disease. We can now measure the levels of oxygen in kidney tissue in rats 24 hours a day, 7 days a week, in a completely non-invasive way. We will study two common kinds of kidney disease. One, acute kidney injury, can result from administration of contrast agents used in x-ray diagnostic procedures. The other, chronic kidney disease, is common in patients with diabetes or high blood pressure.

我们将确定肾脏中的低氧水平如何导致肾脏疾病。我们现在可以每天24小时，每周7天，以一种完全无创的方式，测量大鼠肾脏组织中的氧含量。我们将学习两种常见的肾脏疾病。一种是急性肾损伤，可由x线诊断过程中使用的造影剂引起。另一种是慢性肾病，常见于糖尿病或高血压患者。