Repair of the nigrostriatal pathway by phenotype shift of dopamine neurones

通过多巴胺神经元表型转变修复黑质纹状体通路

• 批准号: nhmrc : 628480
• 负责人: A/Pr Phillip Dickson
• 金额: $ 37.44万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/repair-nigrostriatal-pathway-dopamine-neurones/97305
• 关键词: Repair; nigrostriatal; pathway; phenotype; shift

Repairing the injured brain will depend on developing new cells that can form the correct cell type, make the right connections and be incorporated into normal brain circuitry. We have found that dopamine cells, which are lost in Parkinson's Disease, are being renewed in the adult rodent brain. This study is directed at finding factors that control this process and to exploit these factors therapeutically. We provide evidence that this can be used to treat Parkinson's Disease.

修复受伤的大脑将取决于开发新的细胞，这些细胞可以形成正确的细胞类型，进行正确的连接并被纳入正常的大脑回路。我们发现，在帕金森氏症中丢失的多巴胺细胞在成年啮齿动物的大脑中得到了更新。本研究旨在寻找控制这一过程的因素，并利用这些因素进行治疗。我们提供的证据表明，这可以用来治疗帕金森病。