Repairing Cochlear Synaptopathy

修复耳蜗突触病

• 批准号: nhmrc : 1142910
• 负责人: A/Pr James Fallon
• 金额: $ 46.03万
• 依托单位: The Bionic Ear Institute
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/repairing-cochlear-synaptopathy/1319815
• 关键词: Repairing; Cochlear; Synaptopathy

Most adults will have already sustained damage to the tiny connections between hearing cells and nerve cells; a missing link in their auditory pathway. There is no way to repair the damage and our hearing will worsen over time. We now have compelling evidence that a growth factor therapy to the inner ear restores the connections. We will deliver world-first data to justify and set the parameters for a clinical trial for a therapy to treat hearing loss for the first time.

大多数成年人的听觉细胞和神经细胞之间的微小连接已经受到损害，这是听觉通路中缺失的一环。没有办法修复损伤，我们的听力会随着时间的推移而恶化。我们现在有令人信服的证据表明，对内耳的生长因子治疗可以恢复连接。我们将提供世界第一的数据，以证明和设置参数的临床试验，治疗听力损失的第一次。