Repairing Cochlear Synaptopathy

修复耳蜗突触病

• 批准号: nhmrc : GNT1142910
• 负责人: A/Pr James Fallon
• 金额: $ 68.07万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/repairing-cochlear-synaptopathy/1348486
• 关键词: Repairing; Cochlear; Synaptopathy

Most adults will have already sustained damage to the tiny connections between hearing cells and nerve cells; a missing link in their auditory pathway. There is no way to repair the damage and our hearing will worsen over time. We now have compelling evidence that a growth factor therapy to the inner ear restores the connections. We will deliver world-first data to justify and set the parameters for a clinical trial for a therapy to treat hearing loss for the first time.

大多数成年人的听觉细胞和神经细胞之间的微小连接已经受到损害；听觉通路中缺失的一环。这种损伤是无法修复的，我们的听力会随着时间的推移而恶化。我们现在有令人信服的证据表明，对内耳进行生长因子治疗可以恢复这些连接。我们将提供世界上第一个数据来证明并为治疗听力损失的治疗方法的临床试验设置参数。