Research Fellowship - Grant ID:1020317

研究奖学金 - 拨款 ID：1020317

• 批准号: nhmrc : 1020317
• 负责人: Prof Michael Waters
• 金额: $ 55.64万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/research-fellowship-grant-id1020317/110018
• 关键词: Research; Fellowship; Grant; ID; 1020317

I study hormone action at the molecular level, particularly that of growth hormone action. I focus on the mechanism of activation of its receptor, notably as a target for cancer therapy, since growth hormone is necessary for the progression of many types of cancer. The ability of growth hormone to activate neural stem cells for a prolonged period in response to voluntary exercise is also a key interest. So too is the 40% extension of lifespan in mice after genetically deleting the growth hormone receptor.

我在分子水平上研究激素作用，特别是生长激素的作用。我专注于其受体的激活机制，特别是作为癌症治疗的靶点，因为生长激素对于许多类型的癌症的进展是必需的。生长激素长期激活神经干细胞以响应自愿运动的能力也是一个关键兴趣点。通过基因删除生长激素受体后，小鼠的寿命延长了 40%。