Role of STAT5 in defining lifespan in mouse models

STAT5 在定义小鼠模型寿命中的作用

• 批准号: nhmrc : 1025094
• 负责人: Prof Michael Waters
• 金额: $ 36.49万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-stat5-defining-mouse-models/110404
• 关键词: Role; STAT5; defining; lifespan; mouse

We seek to elucidate the molecular basis for the extended lifespan seen in the Methuselah mouse, the longest lived mouse model of ageing. This mouse lacks the receptor for growth hormone, and we have identified a major gene-regulating protein activated by the growth hormone receptor as correlating with lifespan. This project seeks to establish if this protein does indeed regulate lifespan, and to determine how it does this, particularly in relation to metabolism of toxins and free radicals.

我们试图阐明在Matuselah小鼠身上看到的延长寿命的分子基础，这是寿命最长的衰老小鼠模型。这只小鼠缺乏生长激素受体，我们已经鉴定出一种主要的基因调节蛋白，由生长激素受体激活，与寿命相关。这个项目试图确定这种蛋白质是否真的调节寿命，并确定它是如何做到这一点的，特别是与毒素和自由基代谢有关的。