Resetting the tipping point: Converting immune checkpoint non-responders into responders.

重置临界点：将免疫检查点无反应者转变为反应者。

• 批准号: nhmrc : 1103980
• 负责人: Dr Anthony Bosco
• 金额: $ 31.21万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/resetting-tipping-point-responders-responders/662713
• 关键词: Resetting; tipping; point; Converting; immune

Although immunotherapy has recently shown a breakthrough in the treatment of lung cancers, with long-term full regression of the cancer in some patients, most patients unfortunately do not respond. In this proposal, we want to characterise the events that occur in a cancer that is cured by immunotherapy, while it regresses. By subsequently reinforcing those processes, we aim to tip the balance towards a response, thereby increasing the cure rate.

尽管免疫疗法最近在肺癌治疗方面取得了突破，一些患者的癌症长期完全消退，但不幸的是大多数患者没有反应。在这个提案中，我们希望解释通过免疫疗法治愈的癌症中发生的事件，而它会消退。通过随后加强这些过程，我们的目标是使平衡向反应倾斜，从而提高治愈率。