Rogue B cell clones in Patients with Autoimmune Disease

自身免疫性疾病患者中的流氓 B 细胞克隆

• 批准号: nhmrc : 1142186
• 负责人: Dr Joanne Reed
• 金额: $ 61.98万
• 依托单位: Garvan Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/rogue-b-cell-autoimmune-disease/1319644
• 关键词: Rogue; cell; clones; Patients; Autoimmune

Our immune system protects us from disease by producing antibodies. However, 5% of Australians suffer from an autoimmune disease where they produce “auto” antibodies, which attack their own organs. This research will study the cells (termed B cells) responsible for making autoantibodies to determine how they differ from B cells that defend against disease. The goal is to develop therapies that eliminate autoantibody producing B cells from patients while preserving the immune system.

我们的免疫系统通过产生抗体来保护我们免受疾病侵袭。然而，5%的澳大利亚人患有一种自身免疫性疾病，他们会产生“自身”抗体，这种抗体会攻击自己的器官。这项研究将研究负责制造自身抗体的细胞(称为B细胞)，以确定它们与防御疾病的B细胞有何不同。其目标是开发一种治疗方法，在保留免疫系统的同时消除患者体内产生自身抗体的B细胞。