The role of AMPK in suppressing liver steatosis and atherosclerosis

AMPK 在抑制肝脏脂肪变性和动脉粥样硬化中的作用

• 批准号: nhmrc : GNT1156634
• 金额: $ 69.75万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-ampk-suppressing-steatosis-atherosclerosis/1378947
• 关键词: role; AMPK; suppressing; liver; steatosis

Increased fat and cholesterol accumulation can contribute to the development of fatty liver disease and atherosclerosis. The main objective of this project is to understand the control of fat and cholesterol metabolism by a novel signaling cascade in the liver and in specialized immune cells called macrophages. We aim to investigate whether pharmacological activators that stimulate this signaling cascade can significantly improve the condition of fatty liver disease and reduce atherosclerosis.

脂肪和胆固醇积累的增加会导致脂肪肝疾病和动脉粥样硬化的发展。该项目的主要目的是了解脂肪和胆固醇代谢的控制通过一个新的信号级联在肝脏和特殊的免疫细胞称为巨噬细胞。我们的目的是研究刺激这一信号级联的药物激活剂是否能显著改善脂肪肝疾病的病情并减少动脉粥样硬化。