The role of angiopoietin-1 in the self-renewal and metastasis of prostate cancer stem cells

血管生成素-1在前列腺癌干细胞自我更新和转移中的作用

• 批准号: nhmrc : 1031221
• 负责人: Dr Ming Tat (Patrick) Ling
• 金额: $ 37.26万
• 依托单位: Queensland University of Technology
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-angiopoietin-1-stem-cells/110793
• 关键词: role; angiopoietin; self; renewal; metastasis

Bone metastasis occurs in more than 80% of cases of advanced prostate cancer (PCa), and is the major cause of morbidity and mortality in PCa patients. Understanding why PCa cells preferentially metastasize to bone may lead to the the development of novel therapy for inhibiting PCa metastasis. This project will study how the bone cell-secreted protein angiopoietin-1 promotes the metastasis of PCa cells to bone and whether inactivation of this protein can inhibit PCa bone metastasis.

骨转移发生在超过80%的晚期前列腺癌（PCa）病例中，并且是PCa患者发病率和死亡率的主要原因。了解PCa细胞优先转移到骨的原因可能会导致抑制PCa转移的新疗法的发展。本项目将研究骨细胞分泌蛋白血管生成素-1如何促进PCa细胞向骨的转移，以及该蛋白的失活是否可以抑制PCa骨转移。