胰腺癌新生血管形成及侵袭转移的分子调控机制是目前临床医学研究的热点和难点。本课题前期研究发现Reg3α在胰腺癌临床样本中显著高表达，并与Angiopoietin-1的表达水平、新生血管形成及肿瘤侵袭转移正相关；Reg3α重组蛋白刺激能促进血管内皮细胞增殖、迁移，诱导其受体EXTL3活化入核及Angiopoietin-1表达增加；干扰Angiopoietin-1可有效降低Reg3α促新生血管形成的生物学功能。由此，本课题推测Reg3α可通过促进Angiopoietin-1转录，介导胰腺癌新生血管形成和侵袭转移。本课题拟从临床样本验证、细胞及动物实验多个层面，进一步证实Reg3α与胰腺癌临床特征及预后的相关性，明确其生物学功能及通过与EXTL3结合促进Angiopoietin-1转录的作用，旨在阐明Reg3α在胰腺癌中异常表达的调控机制，为临床诊断、预防及治疗胰腺癌提供新的分子靶标和研究思路。

The underlying mechanism of the angiogenesis, tumor invasion and metastasis are important to the clinical therapy of pancreatic cancer. Our previous study had found that Reg3α (regenerating islet-derived protein 3α) was highly expressed in pancreatic cancer tissues, which was related to the expression level of Angiopoientin-1 and angiogenesis in pancreatic cancer. And using of recombinant Reg3α, the proliferation and migration of vessel epithelial cells were improved. Reg3α might induce its receptor EXTL3 translocation into nucleus, thereby increasing the expression of Angiopoietin-1. Moreover, interference of Angiopoietin-1 pathway could reduce the pro-angiogenesis effect of Reg3α. Therefore, Reg3α could strongly associated with the angiogenesis in pancreatic cancer via regulating Angiopoietin-1 signal. This study would further investigate the relationship of Reg3α and angiogenesis in pancreatic cancer according to clinical study, in vitro and in vivo experiments. Further exploration of the biological effect of Reg3α on angiogenesis should provide benefit to the diagnosis and treatment of pancreatic cancer.