The role of capsid protein nucleolar localisation in chikungunya virus: implications for vaccine development

衣壳蛋白核仁定位在基孔肯雅病毒中的作用：对疫苗开发的影响

• 批准号: nhmrc : 1122897
• 金额: $ 35.58万
• 依托单位: Griffith University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-capsid-protein-vaccine-development/947050
• 关键词: role; capsid; protein; nucleolar; localisation

Chikungunya virus (CHIKV) is a globally widespread mosquito-borne alphavirus capable of causing considerable human morbidity and mortality. With no CHIKV vaccine or antiviral available this proposal aims to develop a live attenuated CHIKV vaccine, rationally designed by investigating the host cell nucleolar trafficking of CHIKV capsid protein. This vaccine has the potential to provide cross-protection against additional arthritogenic alphaviruses endemic to Australia such as Ross River virus.

基孔肯雅病毒（CHIKV）是一种全球广泛传播的蚊媒甲病毒，能够引起相当大的人类发病率和死亡率。由于没有可用的CHIKV疫苗或抗病毒剂，该提议旨在开发减毒活CHIKV疫苗，通过研究CHIKV衣壳蛋白的宿主细胞核仁运输来合理设计。该疫苗有可能提供针对澳大利亚特有的其他致关节炎甲病毒（如罗斯河病毒）的交叉保护。