The role of cell adhesion molecules in regulation of axon advance

细胞粘附分子在轴突前进调节中的作用

• 批准号: nhmrc : 509317
• 负责人: A/Pr Paul Whitington
• 金额: $ 28.41万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-cell-adhesion-axon-advance/82698
• 关键词: role; cell; adhesion; molecules; regulation

All cells contain on their surface a class of molecules, cell adhesion molecules, that enable them to adhere to other cells in tissues. Cell adhesion molecules have long been known to be involved in the guidance of axons to their targets during development. However the molecular mechanisms by which these molecules act are largely unknown. We propose to use the powerful genetic tools available in the fruitfly to dissect the mechanisms by which two cell adhesion molecules promote axon growth.

所有的细胞表面都含有一类分子，细胞粘附分子，使它们能够附着在组织中的其他细胞上。细胞粘附分子长期以来一直被认为参与轴突在发育过程中到达目标的引导。然而，这些分子作用的分子机制在很大程度上是未知的。我们建议使用强大的遗传工具在果蝇中可用来解剖两种细胞粘附分子促进轴突生长的机制。