Role of Chemoattractants in Hepatic Stellate Cell Recruitment and Fibrogenesis in Paediatric Cholestatic Liver Disease.

化学引诱剂在小儿胆汁淤积性肝病肝星细胞募集和纤维形成中的作用。

• 批准号: nhmrc : 496602
• 负责人: A/Pr Peter Lewindon
• 金额: $ 39.29万
• 依托单位: Queensland Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-chemoattractants-hepatic-liver-disease/96281
• 关键词: Role; Chemoattractants; Hepatic; Stellate; Cell

This project investigates how decreased bile flow in children's liver diseases such as cystic fibrosis and biliary atresia, leads to the release of molecules from the liver which cause recruitment of scar-forming cells. This results in cirrhosis (liver scar) and the necessity for liver transplantation. This project will investigate whether some children are more susceptible to liver scarring due to mutations in genes which cause increased release of these recruitment molecules from the liver.

该项目研究了儿童肝脏疾病（如囊性纤维化和胆道闭锁）中胆汁流量的减少如何导致肝脏释放分子，从而导致瘢痕形成细胞的招募。这导致肝硬化（肝瘢痕）和肝移植的必要性。该项目将调查是否一些儿童更容易由于基因突变导致这些招募分子从肝脏释放增加而导致肝脏瘢痕形成。