Role of common genetic variation driving single cell transcriptional heterogeneity across the cardiomyocyte lineage

常见遗传变异在心肌细胞谱系中驱动单细胞转录异质性的作用

• 批准号: nhmrc : GNT1143163
• 负责人: A/Pr Joseph Powell
• 金额: $ 88.27万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-common-genetic-cardiomyocyte-lineage/1348507
• 关键词: Role; common; genetic; variation; driving

In human tissues, most mature cells develop by differentiation from pluripotent stem cells. As they undergo differentiation, their transcriptional activity changes dramatically. Many of the genetic causes for these changes are unknown, which limits research in the use of stem cells for treating and modelling disease. This proposal addresses this problem with cardiac muscle cell differentiation by utilising recent developments in biotechnology that enables individual cells to be sequenced.

在人体组织中，大多数成熟细胞通过从多能干细胞分化而发育。当它们经历分化时，它们的转录活性发生显著变化。这些变化的许多遗传原因尚不清楚，这限制了利用干细胞治疗和建模疾病的研究。该提案通过利用生物技术的最新发展解决了心肌细胞分化的问题，该生物技术使单个细胞能够被测序。