Control of genome regulation and its role in human disease

基因组调控的控制及其在人类疾病中的作用

• 批准号: nhmrc : GNT1107599
• 负责人: A/Pr Joseph Powell
• 金额: $ 41.92万
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/control-genome-regulation-human-disease/1346592
• 关键词: Control; genome; regulation; its; role

Changes in DNA can lead to differences in susceptibility to developing many diseases. The most common mechanism by which this occurs is through changing when and in which tissues disease-relevant genes get translated into proteins. My research focuses on understanding how DNA changes result in altered gene expression and how this can affect disease susceptibility. This work requires the use of high performance computing and statistical analysis of large genome-scale datasets.

DNA的变化可以导致对许多疾病的易感性的差异。发生这种情况的最常见机制是通过改变疾病相关基因何时以及在哪些组织中翻译成蛋白质。我的研究重点是了解DNA的变化如何导致基因表达的改变，以及这如何影响疾病的易感性。这项工作需要使用高性能计算和大型基因组规模数据集的统计分析。