The Role of Crim1 in Cardiovascular Development

Crim1 在心血管发育中的作用

• 批准号: nhmrc : 631658
• 负责人: Dr David Pennisi
• 金额: $ 43.25万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-crim1-cardiovascular-development/101509
• 关键词: Role; Crim1; Cardiovascular; Development

Coronary artery disease is the largest single cause of death in Australia, and commonly manifests as heart attack and angina. Congenital heart disease is the most common birth defect. We have identified a gene, Crim1, that is important for heart and coronary artery development. Investigating how this gene functions will lead to a greater understanding of congenital heart disease and may lay the foundation for therapeutics to regenerate damaged hear tissue.

冠状动脉疾病是澳大利亚最大的单一死因，通常表现为心脏病发作和心绞痛。先天性心脏病是最常见的出生缺陷。我们已经确定了一个基因，E111，这是心脏和冠状动脉发育的重要。研究这种基因的功能将有助于更好地了解先天性心脏病，并可能为再生受损心脏组织的治疗方法奠定基础。