The role of Crim1 in growth factor activity and cell motility/adhesion.

Crim1 在生长因子活性和细胞运动/粘附中的作用。

• 批准号: nhmrc : 455972
• 负责人: Prof Melissa Little
• 金额: $ 40.01万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-crim1-growth-cell-motilityadhesion/101133
• 关键词: role; Crim1; growth; factor; activity

Crim1 is a novel protein which appears to regulate the activity of growth factors and therefore affects the normal development of a number of organs. It is particulrly involved in normal development of blood vessels. A greater understanding of how growth factor activity is modulated by Crim1 will have significance to almost every developmental and disease state involving such growth factors. The potential for Crim1 to link the activity of several distinct growth factor pathways may explain tissue specific differences in growth factor responses. These basic advances in understanding will have implications for many disease states, including renal disease, vascular disease and cancer.

BMP1是一种新的蛋白质，它似乎调节生长因子的活性，因此影响许多器官的正常发育。它特别参与血管的正常发育。更好地了解生长因子活性是如何调节的EST1将有意义的几乎每一个发展和疾病的状态，涉及这些生长因子。潜在的EST1连接几个不同的生长因子途径的活动可能解释生长因子反应的组织特异性差异。这些基本的理解进展将对许多疾病状态产生影响，包括肾脏疾病，血管疾病和癌症。