The role of Cytochrome P-450 metabolites of Arachidonic acid in human cardiovascular disease

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Alcohol consumption is known to raise blood pressure but the mechanism by which it does this is not known This project examines the role of certain fatty acid metabolites called cytochrome P450 metabolites of arachidonic acid (CYP450AA-M) during periods of alcohol consumption and periods of abstinance from alcohol. These fatty acid metabolites act on blood vessels causing them to constrict or dilate. In doing this they affect blood pressure regulation. The results of this study will determine how important CYP450AA-M are in the development of alcohol related hypertension. We will study CYP450AA-M in cells as well as in plasma and urine to see if cellular levels of CYP450AA-M are better determinants of blood pressure regulation than plasma or urinary levels of CYP450AA-M. This project will help scientists decide how important these metabolites are for blood presssure regulation. If these metabolites are found to be important then it should be possible to alter their levels either by diet or drug treatment.