The role of Cytochrome P-450 metabolites of Arachidonic acid in human cardiovascular disease

花生四烯酸细胞色素P-450代谢物在人类心血管疾病中的作用

• 批准号: nhmrc : 458514
• 负责人: E/Pr Lawrie Beilin
• 金额: $ 36.85万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-cytochrome-p-cardiovascular-disease/97299
• 关键词: role; Cytochrome; 450; metabolites; Arachidonic

Alcohol consumption is known to raise blood pressure but the mechanism by which it does this is not known This project examines the role of certain fatty acid metabolites called cytochrome P450 metabolites of arachidonic acid (CYP450AA-M) during periods of alcohol consumption and periods of abstinance from alcohol. These fatty acid metabolites act on blood vessels causing them to constrict or dilate. In doing this they affect blood pressure regulation. The results of this study will determine how important CYP450AA-M are in the development of alcohol related hypertension. We will study CYP450AA-M in cells as well as in plasma and urine to see if cellular levels of CYP450AA-M are better determinants of blood pressure regulation than plasma or urinary levels of CYP450AA-M. This project will help scientists decide how important these metabolites are for blood presssure regulation. If these metabolites are found to be important then it should be possible to alter their levels either by diet or drug treatment.

酒精消费是已知的，以提高血压，但它这样做的机制尚不清楚这个项目检查的作用，某些脂肪酸代谢物称为细胞色素P450代谢物的花生四烯酸（CYP 450 AA-M）在饮酒期间和戒酒期间。这些脂肪酸代谢物作用于血管，使其收缩或扩张。这样做会影响血压调节。本研究的结果将确定CYP 450 AA-M在酒精相关高血压的发展中的重要性。我们将研究细胞以及血浆和尿液中的CYP 450 AA-M，以确定细胞水平的CYP 450 AA-M是否比血浆或尿液水平的CYP 450 AA-M更好地决定血压调节。该项目将帮助科学家确定这些代谢物对血压调节的重要性。如果发现这些代谢物是重要的，那么应该可以通过饮食或药物治疗来改变它们的水平。