Effects of omega-3 fatty acids and coenzyme Q10 on cardiovascular risk in chronic renal failure

omega-3 脂肪酸和辅酶 Q10 对慢性肾功能衰竭心血管风险的影响

• 批准号: nhmrc : 303151
• 负责人: E/Pr Lawrie Beilin
• 金额: $ 28.92万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2004
• 资助国家: 澳大利亚
• 起止时间: 2004-01-01 至 2006-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/effects-omega-3-renal-failure/81251
• 关键词: Effects; omega; fatty; acids; coenzyme

Heart disease is one of the main causes of death in Australia. People with chronic renal failure (CRF) are at increased cardiovascular risk due to the coexistence of hypertension (high blood pressure), blood lipid abnormalities, and increased inflammation and oxidative stress. One approach may be to complement drug treatment of CRF with non-drug measures such as nutrition and lifestyle factors. In this regard, omega-3 fatty acids have great clinical potential in the treatment of CRF and its associated complications. Omega-3 fatty acids reduce blood pressure and blood vessel wall elasticity, they improve blood fats, reduce the tendency of blood to clot, and attenuate inflammation and oxidative stress. Coenzyme Q10 is an antioxidant that plays a critical role in cellular function. It improves blood pressure, blood vessel and heart function, and glucose control. It is proposed that the impact of a combined approach of supplementation of omega-3 fatty acids given as fish oils and coenzyme Q10, will lead to beneficial composite effects on blood pressure and heart disease risk in patients with mild-to-moderate chronic renal failure. In the proposed study, patients will undergo medical and biochemical assessment during a 3-week baseline period, after which they will be allocated to either supplement their normal diet with either 4g of encapsulated fish oil or placebo per day. Within each of these groups they will be further assigned to take coenzyme Q10 capsules (200mg) or placebo capsules. All measurements will be repeated at the end of 8 weeks.

心脏病是澳大利亚的主要死因之一。慢性肾功能衰竭(CRF)患者由于高血压(高血压)、血脂异常以及炎症和氧化应激增加而增加心血管风险。一种方法可能是用营养和生活方式因素等非药物措施来补充CRF的药物治疗。在这方面，omega-3脂肪酸在治疗CRF及其相关并发症方面具有巨大的临床潜力。Omega-3脂肪酸降低血压和血管壁弹性，它们改善血脂，减少血液凝结的倾向，并减轻炎症和氧化应激。辅酶Q10是一种抗氧化剂，在细胞功能中起着关键作用。它可以改善血压、血管和心脏功能，以及血糖控制。有人提出，补充作为鱼油和辅酶Q10的omega-3脂肪酸的联合方法的影响，将导致对轻中度慢性肾功能衰竭患者的血压和心脏病风险产生有益的综合效应。在这项拟议的研究中，患者将在3周的基准期内接受医学和生化评估，之后他们将被分配到每天补充4G胶囊鱼油或安慰剂的正常饮食中。在每一组中，他们将被进一步分配服用辅酶Q10胶囊(200 Mg)或安慰剂胶囊。所有测量将在8周结束时重复进行。