A role for double-stranded RNA-dependent protein kinase in regulating Nod-like receptor signaling for modulating colitis and colitis-associated cancer.

双链 RNA 依赖性蛋白激酶在调节 Nod 样受体信号传导以调节结肠炎和结肠炎相关癌症中的作用。

• 批准号: nhmrc : 1052730
• 负责人: Dr Howard Yim
• 金额: $ 15.38万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-double-stranded-associated-cancer/112294
• 关键词: role; double; stranded; RNA; dependent

Inflammatory bowel disease (IBD) and Colorectal cancers (CRC) are commonly found in developed countries like Australia. In spite of improved treatment for IBD and CRC, it is still not known why many patients are still not responsive to these therapies. Therefore, this proposed project aims to use genetically modified mice and molecular biology techniques to understand the pathogenesis of these diseases and to find an alternative new treatment for these diseases.

炎症性肠病（IBD）和结直肠癌（CRC）在澳大利亚等发达国家很常见。尽管IBD和CRC的治疗方法有所改善，但仍不清楚为什么许多患者对这些治疗没有反应。因此，本项目旨在利用转基因小鼠和分子生物学技术来了解这些疾病的发病机制，并为这些疾病找到一种新的治疗方法。