The role of ephrinB1 reverse signalling in osteogenic differentiation during skeletal development and osteoporosis

ephrinB1 反向信号在骨骼发育和骨质疏松过程中成骨分化中的作用

• 批准号: nhmrc : 1083704
• 负责人: Dr Agnieszka Arthur
• 金额: $ 37.83万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-ephrinb1-reverse-development-osteoporosis/518952
• 关键词: role; ephrinB1; reverse; signalling; osteogenic

The present proposal will identify the importance of ephrinB1 during the deregulation of bone remodelling that occurs in osteoporosis, by deleting ephrinB1 in committed osteoblast precursor cells in a mouse model of osteoporosis. Knowledge gained from this proposal could potentially translate into alternative therapeutic treatment strategies for patients with osteoporosis with the use of Eph/ephrin targeted drugs currently being developed for cancer treatment.

本提案将通过在骨质疏松症小鼠模型中删除已承诺的成骨细胞前体细胞中的estaginB1，来确定在骨质疏松症发生的骨重塑解除调控过程中ePhrinB1的重要性。从这项提议中获得的知识可能会转化为骨质疏松症患者的替代治疗策略，目前正在开发用于癌症治疗的Eph/EPhin靶向药物。