The role of ephrinB1 reverse signalling in osteogenic differentiation during skeletal development and osteoporosis
The role of ephrinB1 reverse signalling in osteogenic differentiation during skeletal development and osteoporosis
ephrinB1 反向信号在骨骼发育和骨质疏松过程中成骨分化中的作用
批准号：
nhmrc : 1083704
负责人：
Dr Agnieszka Arthur
金额：
$37.83万
依托单位国家：
澳大利亚
项目类别：
Project Grants
财政年份：
2015
资助国家：
澳大利亚
项目状态：
已结题
起止时间：
2015-01-01 至 2017-12-31
中文摘要
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英文摘要
The present proposal will identify the importance of ephrinB1 during the deregulation of bone remodelling that occurs in osteoporosis, by deleting ephrinB1 in committed osteoblast precursor cells in a mouse model of osteoporosis. Knowledge gained from this proposal could potentially translate into alternative therapeutic treatment strategies for patients with osteoporosis with the use of Eph/ephrin targeted drugs currently being developed for cancer treatment.
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海外基金
Notch1通路激活并上调ephrinB1表达在促骨肉瘤细胞“干性”及增加化疗耐药中的作用与机制
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批准号：81802689
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项目类别：青年科学基金项目
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资助金额：20.0万元
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批准年份：2018
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负责人：高天
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依托单位：
