The role of ephrinB1 and ephrinB2 in controling gamma-delta T cell development

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The applicant is a pioneer in Eph/ephrin research. This research has been a major program (with funding from other sources) in his lab since 2000. The short-term objectives described hereafter to be carried out in the next 5 years are a part of a long-term program, which will be in full swing for the next 10 years and more, and the objectives of which are to elucidate the roles of Ephs/ephins in the immune system and cardiovascular system. Three to six Ph.D. students will be trained in the next 10 years using the program as a vehicle. This long-term program will be a dedicated NSERC program.