The role of the HuB RNA-binding protein in post-transcriptional gene regulation in the pre-gastrula zebrafish embryo

HuB RNA结合蛋白在前原肠胚斑马鱼胚胎转录后基因调控中的作用

• 批准号: nhmrc : 565424
• 负责人: Dr Belinda Dredge
• 金额: $ 36.36万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-hub-rna-zebrafish-embryo/82154
• 关键词: role; HuB; RNA; binding; protein

The precise control of protein expression is absolutely critical in biology. The key decisions about which genes are turned on or off at any one moment control the proper growth of an organism during development, and are responsible for the organism's homeostasis and proper response to environmental changes as an adult. The spatio-temporal control of genes is critcal during embryogenesis and we aim to understand how these processes underlie development in the vertebrate embryo.

蛋白质表达的精确控制在生物学中是绝对关键的。在任何一个时刻打开或关闭哪些基因的关键决定控制着生物体在发育过程中的正常生长，并负责生物体的稳态和成年后对环境变化的适当反应。基因的时空调控在胚胎发生过程中至关重要，我们的目标是了解这些过程是如何在脊椎动物胚胎发育的基础。