Understanding the post-transcriptional regulatory roles of the Hu family of RNA-binding proteins using HITS-CLIP

使用 HITS-CLIP 了解 Hu 家族 RNA 结合蛋白的转录后调控作用

• 批准号: nhmrc : 1033391
• 负责人: Dr Belinda Dredge
• 金额: $ 39.24万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-post-transcriptional-hits-clip/110890
• 关键词: Understanding; post; transcriptional; regulatory; roles

Differentiation of embryonic stem cells into differentiated states such as neurons requires complex changes in a cell's post-transcriptional gene regulation. The Hu family of proteins likely plays a critical role in this regulation, as they can bind message untranslated regions and change whether these messages ultimately make protein products or not. In this application we investigate the function of the Hu proteins in regulating specific mRNAs that we have recently identified.

胚胎干细胞分化为神经元等分化状态需要细胞转录后基因调控的复杂变化。 Hu 蛋白家族可能在这种调节中发挥着关键作用，因为它们可以结合信息非翻译区域并改变这些信息最终是否产生蛋白质产品。在此应用中，我们研究了 Hu 蛋白在调节我们最近鉴定的特定 mRNA 中的功能。