The Role of Hox Genes in Myeloid Cell Development and Myeloid Leukaemia

Hox 基因在髓系细胞发育和髓系白血病中的作用

• 批准号: nhmrc : 546438
• 负责人: A/Pr Paul Ekert
• 金额: $ 39.43万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-hox-genes-myeloid-leukaemia/81468
• 关键词: Role; Hox; Genes; Myeloid; Cell

The transformation of normal white blood cells into leukaemic cells occurs as a result of changes to the genes of those cells. These changes are often characteristic of particular cancers and carry diagnostic and prognostic significance. This work will determine how critical some of the typical genetic changes of leukaemia are to the occurrence and persistence of cancer. Importantly, we will determine whether targeting these changes can provide new and effective approaches to treatment.

正常白色血细胞转化为白血病细胞是由于这些细胞的基因发生变化。这些变化通常是特定癌症的特征，并具有诊断和预后意义。这项工作将确定白血病的一些典型遗传变化对癌症的发生和持续有多重要。重要的是，我们将确定针对这些变化是否可以提供新的有效的治疗方法。