Molecular characterisation of a new survival pathway in haematopoietic cells

造血细胞新生存途径的分子表征

• 批准号: nhmrc : 1022916
• 负责人: A/Pr Paul Ekert
• 金额: $ 38.12万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/molecular-characterisation-new-haematopoietic-cells/110228
• 关键词: Molecular; characterisation; new; survival; pathway

It is critical for normal health that cells regulate their responses to changes in the the extracellular environment. Receptors on the cell surface are triggered by specific proteins called cytokines, and relay information to the cell interior. These messages include signaling whether cells should survive and proliferate. Inappropriate activation of signals for survival and proliferation is a hallmark of cancer. We are investigating a new survival signal and how this contributes to the survival of normal cells and to diseases such as leukaemia.

细胞调节其对细胞外环境变化的反应对正常健康至关重要。细胞表面的受体被称为细胞因子的特定蛋白质触发，并将信息传递到细胞内部。这些信息包括细胞是否应该存活和增殖的信号。存活和增殖信号的不适当激活是癌症的标志。我们正在研究一种新的生存信号，以及它如何有助于正常细胞的生存和白血病等疾病。